A SIMPLE ONE-POT SYNTHESIS OF PYRIMIDO[4,5-C]PYRIDAZINES AND IN SILICO STUDIES OF HUMAN AKT1 INHIBITORS

A simple one-pot and efficient synthetic method for the synthesis of pyrimido[4,5-c]pyridazine by a multicomponent reaction. The compounds are study their inhibitory activities towards AKT1 pathways using in silico method. It was found that all have binding energy lower than -7.9 kcal/mol compound 3a is most active with -9.65 kcal/mol, which been performed autodock vina.